Chapter 123 Extraction
In the classroom of the Supervisory Building of the Academy, Yang Yu raised his hand and asked, "Doctor, why didn't Li Ang come to class?"
"He's doing a very important study."
Doctor of Computing Chao Wenyuan said with a straight face: "Not only today's class, but you won't be able to see him for some time to come."
"ah?"
Yang Yu and the others were astonished, and subconsciously asked: "What research takes so long? How did Jijiu agree to grant such a long leave?"
"It's not arithmetic anyway!"
Chao Wenyuan patted down the table, blew his beard and stared at him, and muttered something in his mouth, "Such a good seed, if you don't come to study arithmetic, it's a waste of money."
——
Outside the Patent Office of the Academy, Hu merchants and Jing country merchants dressed in gorgeous silk costumes were holding stacks of flying money banknotes, and surrounded Su Feng, a doctor of science.
"Dr. Su Feng, where is that Mr. Li Xiaolang? Didn't you say you can see him in a few days?"
"Yes, Dr. Su Feng, we have all the money ready. Just wait for his permission, and we will ship the goods back."
"Doctor, our caravan eats horse chews in Chang'an City, and it costs money every day. I really can't afford to wait. Please ask Mr. Li Xiaolang, please."
The large stacks of flying money waved by the merchants made the apprentices in the patent office dizzy,
Su Feng had no choice but to let go of the monk's aura and shake off the crowd a little, "I'm really sorry, I can't help with this. Li Ang is very busy at this time, and I don't see outsiders. You should go home and wait for the notice."
——
North of Chang'an City, Daming Palace, Hanxiang Hall.
"The little doctor Li didn't come? Didn't you tell him that it was for the emperor's heir?"
Concubine Zheng Gui, who was born in Qiwang with five surnames, sat on a bench, caressing her pregnant belly in October, and sharply scolded the servant kneeling in the hall.
"Sister, don't be angry, it's not good for the emperor's heir."
Another concubine Lu, who was also from Qiwang of the five surnames, comforted her softly, looked at the servant and said, "Go to the academy again and say that the imperial doctor said that the delivery date is only a few days away. Please, Mrs. Li, The doctor came to Daming Palace every day after returning home from school.
Don't delay anything,
When the emperor’s heir is born safely, the Zheng family will remember his kindness.”
As the concubine surnamed Lu was talking, she suddenly noticed the frightened expression on the eunuch's face, paused, and said hesitantly: "Did you not see that little doctor Li, or did the academy simply not let you in? Who came forward to stop you?" ?”
"It is sacrificial wine."
The **** lowered his head and said in a trembling voice, "Let me bring a sentence to the two noble concubines for the sacrificial wine."
The two noble concubines stood up together, "What are you talking about?"
"Everyone, be quiet."
——
In the afternoon, Chai Cuiqiao, who was taken to the foot of the back mountain by the school carriage, jumped out of the carriage with large and small packages.
"Master."
Unknown why, Chai Cuiqiao glanced at the carriage quietly driving away, turned to look at Li Ang standing at the intersection, and said doubtfully, "This is us."
"In the next few days, we will live in the academy."
Li Ang smiled apologetically, took the package in Chai Cuiqiao's hand, and led her to an unnamed pavilion at the foot of the back mountain.
The first floor of the pavilion is full of experimental equipment, and the second floor is the bedroom.
Xuegong attaches great importance to blood carbuncle drugs,
Jijiu, who got the news, applied to the head of the mountain and provided Li Ang with an entire pavilion as an experiment site, and granted a long vacation at one time, and he would not lose credits if he did not take courses such as Yulu and National History.
"What's this?"
Chai Cuiqiao put down the change of clothes and toiletries, and poked the flask on the table curiously.
"This is the distillation flask, this is the condenser tube, this is the vacuum introduction tube, this is the receiving bottle, and this is the capillary tube."
Li Ang introduced the experimental instruments to Chai Cuiqiao like a treasure, and these things were all made of hot glass by the monks in the academy using their thoughts.
"What about this one?"
Chai Cuiqiao pointed to a huge metal device with a cylindrical structure next to the wooden table.
"Simple circulating water vacuum pump."
Li Ang said with a smile: "The impeller rotor is eccentrically installed in the cylindrical pump casing, and the blades of the rotor are inclined forward.
The pump body is filled with an appropriate amount of water as the working fluid. When the impeller rotor rotates, the working water will form a water ring that swirls along the pump casing under centrifugal action.
There is a certain space between the closed rotating water ring and the impeller rotor, and the air can be pumped out when it rotates repeatedly.
The faster it turns, the more efficient it is at pumping air. "
"Well"
Chai Chai blinked, "What is the function of this pump?"
"Reduce pressure, even create a vacuum."
Li Ang waved his hand and said casually: "Of course, in this experiment, its main function is to carry out vacuum distillation.
and something distilled."
Li Ang brought up a large bag from under the table and threw it on the table.
"This is."
Chai Chai said in astonishment: "Garlic?"
"Exactly."
Li Ang smiled and said: "The antibacterial ingredients that can solve blood carbuncle, or infection and inflammation, are in the garlic."
Diallylthiosulfinate, or allicin, is an organosulfur compound.
It is not an antibiotic, but a broad-spectrum antibacterial drug.
It has inhibitory and killing effects on various cocci, pertussis bacillus, diphtheria bacillus, Shigella, typhoid and paratyphoid bacillus, tubercle bacillus, etc.
It can even deal with a variety of fungi, viruses, and even amoebas that can cause meningoencephalitis and keratitis, and pinworms that live in the intestines.
Allicin can be used both internally and externally, with less side effects, and it is not easy to cause the corresponding fungi or bacteria to develop drug resistance—because its bactericidal mechanism is mainly to directly destroy enzymes containing thiol groups.
It is extremely difficult for fungi and bacteria to mutate and crack.
And the most common pyogenic coccus - Staphylococcus, happens to be within the killing range of allicin.
Considering the relatively difficult preparation of another antibiotic—penicillin, allicin can almost be said to be the most readily available antibacterial drug at this stage.
The only problem is how to make it.
Fresh garlic does not contain allicin, but only alliin. When the garlic is cut or crushed, alliinase is activated to catalyze the decomposition of alliin into allicin.
To eat garlic raw, according to the effective dose, at least a few kilograms or more than ten kilograms should be eaten at one time.
Must be purified.
In the next few days, Li Ang and Chai Cuiqiao stayed in the pavilion, busy using various methods to extract allicin.
After experiments, there are two most feasible methods for extracting allicin at this stage.
One, steam distillation under reduced pressure.
First peel and wash the garlic, put it into a stone mortar and mash it, pour it into a glass container, pour distilled water and cover it tightly,
Slightly heat in a salt bath to make it enzymatically hydrolyzed,
Then use the circulating water vacuum pump to carry out steam vacuum distillation,
After collecting the distillate, distill under reduced pressure again.
Cycle several times, after getting the solution, put it into a simple refrigerator made of ice trays for storage—allicin is extremely unstable, and loses antibacterial activity when exposed to heat or alkali, and the validity period is very short at room temperature.
Combined with the strong and touching taste and other reasons, it was not able to compete with other antibacterial drugs in the memory of the foreign world.
Second, ethanol extraction method.
Also peel the garlic, wash it, mash it, enzymolyze it with slight heat, pour in different concentrations of ethanol, use a reflux tower to fully dissolve the allicin in the ethanol, wait for several hours, and turn the garlic paste at a speed of more than 1,000 revolutions per minute. Centrifuge at high speed, filter with double-layer rice paper, discard garlic residue,
The filtrate was distilled under reduced pressure and repeated several times to obtain a solution.
The entire extraction process lasted several days,
The master and servant, who were physically and mentally exhausted, looked at the hundreds of test tubes on the table containing allicin, a light yellow oily liquid, and finally smiled.
Condenser tube technology, before that, had a similar application in Xuegong distilled liquor,
The treatment of garlic can also be supported by evidence from previous medical books.
The only problem is that it is too smelly, the process of extracting allicin is simply too smelly.
It’s almost like having a food seminar between canned herring, stinky tofu, and kiviak (Eskimo food made from rotting petrel seals).
Inexplicably, Li Ang recalled the sour smell of some celiac disease lesions in general surgery, and wondered if he was a surgeon specializing in the abdomen in another world.
Even if the windows are fully opened and the breeze talisman is used to ventilate at all times, both the master and the servant feel that they can't stand it.
"Master, I smell so bad."
Chai Chai sniffed his clothes and said with a mournful face.
"It's okay, I stink too."
Li Ang comforted, and asked Chai Chai to go back to Jinchengfang to wash and rest, while he carried a box of test tubes and stepped out of the pavilion.
(end of this chapter)